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| 07.05.2022 | 16:45 | Gallos Blancos | - | CF Pachuca | 0:0 (0:0) | |
| 18:15 | Deportivo Guadalajara | - | UANL Tigres | 2:1 (2:0) | ||
| 18:30 | Cruz Azul | - | Club Necaxa | 1:3 (1:1) | ||
| 18:30 | Santos Laguna | - | Club León | 2:3 (1:2) | ||
| 18:30 | Pumas UNAM | - | Puebla FC | 2:1 (1:1) | ||
| 18:30 | CF Monterrey | - | Club Tijuana | 1:0 (0:0) | ||
| 22:45 | Atlas Guadalajara | - | Atlético San Luis | 2:2 (2:1) | ||
| 23:00 | CF América | - | FC Juárez | 3:0 (3:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Pumas UNAM | 16 | 11 | 5 | 0 | 35:16 | 19 | 38 |
| 2 |
|
Club Necaxa | 16 | 9 | 3 | 4 | 33:19 | 14 | 30 |
| 3 |
|
CF Pachuca | 16 | 9 | 2 | 5 | 40:21 | 19 | 29 |
| 4 |
|
CF América | 16 | 8 | 2 | 6 | 32:23 | 9 | 26 |
| 5 |
|
Deportivo Toluca | 16 | 7 | 4 | 5 | 27:24 | 3 | 25 |
| 6 |
|
FC Juárez | 16 | 6 | 2 | 8 | 20:23 | -3 | 20 |
| 7 |
|
Gallos Blancos | 16 | 5 | 3 | 8 | 14:25 | -11 | 18 |
| 8 |
|
Cruz Azul | 16 | 3 | 2 | 11 | 20:41 | -21 | 11 |
| 9 |
|
Puebla FC | 16 | 2 | 1 | 13 | 11:40 | -29 | 7 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 16 | 12 | 3 | 1 | 38:11 | 27 | 39 |
| 2 |
|
Atlas Guadalajara | 16 | 9 | 4 | 3 | 38:19 | 19 | 31 |
| 3 |
|
UANL Tigres | 16 | 9 | 2 | 5 | 30:25 | 5 | 29 |
| 4 |
|
Club Tijuana | 16 | 8 | 1 | 7 | 31:20 | 11 | 25 |
| 5 |
|
CF Monterrey | 16 | 7 | 4 | 5 | 29:20 | 9 | 25 |
| 6 |
|
Santos Laguna | 16 | 7 | 3 | 6 | 29:29 | 0 | 24 |
| 7 |
|
Club León | 16 | 6 | 4 | 6 | 23:27 | -4 | 22 |
| 8 |
|
Atlético San Luis | 16 | 1 | 2 | 13 | 6:41 | -35 | 5 |
| 9 |
|
Mazatlán FC | 16 | 1 | 1 | 14 | 13:45 | -32 | 4 |
| Playoffs | |
| Playoffs |
