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| H | Cruz Azul | - | Atlante | 0:1 (0:1) | ||
| R | Atlante | - | Cruz Azul | 2:1 (1:0) | ||
| H: 22.11.2007 02:00 | R: 25.11.2007 04:00 | Sieger: Atlante | ||||
| H | Club San Luis | - | Deportivo Guadalajara | 1:1 (0:1) | ||
| R | Deportivo Guadalajara | - | Club San Luis | 1:0 (0:0) | ||
| H: 22.11.2007 04:00 | R: 25.11.2007 02:00 | Sieger: Deportivo Guadalajara | ||||
| H | Monarcas Morelia | - | Santos Laguna | 0:2 (0:1) | ||
| R | Santos Laguna | - | Monarcas Morelia | 3:2 (1:0) | ||
| H: 23.11.2007 02:00 | R: 25.11.2007 23:00 | Sieger: Santos Laguna | ||||
| H | Pumas UNAM | - | Deportivo Toluca | 2:0 (1:0) | ||
| R | Deportivo Toluca | - | Pumas UNAM | 1:1 (1:0) | ||
| H: 23.11.2007 04:00 | R: 25.11.2007 19:00 | Sieger: Pumas UNAM | ||||
