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| 21.10.2005 | 20:00 | SC Cambuur | - | TOP Oss | 1:1 (1:1) | |
| 20:00 | VVV-Venlo | - | HFC Haarlem | 4:1 (4:0) | ||
| 20:00 | Stormvogels Telstar | - | MVV | 1:3 (0:2) | ||
| 20:00 | Go Ahead Eagles | - | De Graafschap | 1:2 (0:1) | ||
| 20:00 | Fortuna Sittard | - | FC Zwolle | 0:2 (0:0) | ||
| 20:00 | FC Eindhoven | - | BV Veendam | 0:1 (0:0) | ||
| 20:00 | FC Den Bosch | - | FC Dordrecht | 2:2 (0:1) | ||
| 20:00 | SBV Excelsior | - | FC Volendam | 3:1 (2:0) | ||
| 20:00 | AGOVV | - | Helmond Sport | 9:1 (4:1) | ||
| 20:00 | FC Emmen | - | FC Omniworld | 5:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VVV-Venlo | 14 | 10 | 3 | 1 | 27:7 | 20 | 33 |
| 2 |
|
SBV Excelsior | 14 | 9 | 3 | 2 | 26:9 | 17 | 30 |
| 3 |
|
FC Volendam | 14 | 9 | 3 | 2 | 25:11 | 14 | 30 |
| 4 |
|
FC Zwolle | 14 | 8 | 4 | 2 | 23:13 | 10 | 28 |
| 5 |
|
FC Den Bosch | 14 | 8 | 3 | 3 | 30:20 | 10 | 27 |
| 6 |
|
FC Emmen | 14 | 8 | 2 | 4 | 30:18 | 12 | 26 |
| 7 |
|
Helmond Sport | 14 | 8 | 2 | 4 | 24:22 | 2 | 26 |
| 8 |
|
MVV | 14 | 6 | 4 | 4 | 22:17 | 5 | 22 |
| 9 |
|
AGOVV | 14 | 6 | 2 | 6 | 30:25 | 5 | 20 |
| 10 |
|
BV Veendam | 14 | 5 | 4 | 5 | 15:16 | -1 | 19 |
| 11 |
|
De Graafschap | 14 | 5 | 4 | 5 | 14:17 | -3 | 19 |
| 12 |
|
FC Dordrecht | 14 | 4 | 5 | 5 | 15:18 | -3 | 17 |
| 13 |
|
Go Ahead Eagles | 14 | 3 | 5 | 6 | 21:27 | -6 | 14 |
| 14 |
|
FC Eindhoven | 14 | 3 | 3 | 8 | 22:26 | -4 | 12 |
| 15 |
|
TOP Oss | 14 | 2 | 5 | 7 | 14:26 | -12 | 11 |
| 16 |
|
SC Cambuur | 14 | 2 | 7 | 5 | 16:19 | -3 | 10 |
| 17 |
|
Stormvogels Telstar | 14 | 1 | 7 | 6 | 12:21 | -9 | 10 |
| 18 |
|
FC Omniworld | 14 | 3 | 1 | 10 | 16:33 | -17 | 10 |
| 19 |
|
HFC Haarlem | 14 | 2 | 3 | 9 | 12:32 | -20 | 9 |
| 20 |
|
Fortuna Sittard | 14 | 1 | 4 | 9 | 13:30 | -17 | 7 |
| Aufstieg |
|
# Cambuur-Leeuwarden bekam 3 Punkte abgezogen. |
