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| 01.04.2022 | 19:00 | Tuzlaspor | - | Ümraniyespor | 1:1 (1:0) | |
| 02.04.2022 | 12:30 | Boluspor | - | Manisa FK | 1:2 (0:1) | |
| 12:30 | Keçiörengücü | - | Bursaspor | 2:1 (1:0) | ||
| 15:00 | İstanbulspor AŞ | - | Gençlerbirliği | 0:0 (0:0) | ||
| 19:30 | Samsunspor | - | Bandırmaspor | 0:1 (0:0) | ||
| 03.04.2022 | 12:30 | Kocaelispor | - | Denizlispor | 1:5 (1:1) | |
| 15:00 | Balıkesirspor | - | BB Erzurumspor | 1:5 (0:2) | ||
| 19:30 | Altınordu FK | - | Adanaspor | 2:0 (0:0) | ||
| 19:30 | MKE Ankaragücü | - | Eyüpspor | 2:3 (2:2) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
MKE Ankaragücü | 29 | 18 | 5 | 6 | 45:23 | 22 | 59 |
| 2 |
|
Ümraniyespor | 29 | 17 | 5 | 7 | 48:28 | 20 | 56 |
| 3 |
|
Bandırmaspor | 29 | 16 | 4 | 9 | 43:25 | 18 | 52 |
| 4 |
|
Eyüpspor | 29 | 13 | 10 | 6 | 44:32 | 12 | 49 |
| 5 |
|
İstanbulspor AŞ | 28 | 14 | 6 | 8 | 44:30 | 14 | 48 |
| 6 |
|
BB Erzurumspor | 29 | 13 | 8 | 8 | 46:34 | 12 | 47 |
| 7 |
|
Samsunspor | 28 | 11 | 9 | 8 | 45:36 | 9 | 42 |
| 8 |
|
Manisa FK | 29 | 11 | 7 | 11 | 33:35 | -2 | 40 |
| 9 |
|
Keçiörengücü | 28 | 10 | 8 | 10 | 36:37 | -1 | 38 |
| 10 |
|
Adanaspor | 29 | 10 | 8 | 11 | 32:30 | 2 | 38 |
| 11 |
|
Boluspor | 28 | 9 | 8 | 11 | 32:33 | -1 | 35 |
| 12 |
|
Tuzlaspor | 28 | 9 | 8 | 11 | 25:29 | -4 | 35 |
| 13 |
|
Menemen Belediyespor | 28 | 8 | 11 | 9 | 36:44 | -8 | 35 |
| 14 |
|
Gençlerbirliği | 28 | 10 | 5 | 13 | 32:42 | -10 | 35 |
| 15 |
|
Altınordu FK | 29 | 11 | 1 | 17 | 33:51 | -18 | 34 |
| 16 |
|
Denizlispor | 28 | 9 | 6 | 13 | 31:40 | -9 | 33 |
| 17 |
|
Kocaelispor | 28 | 9 | 6 | 13 | 27:38 | -11 | 33 |
| 18 |
|
Bursaspor | 28 | 7 | 7 | 14 | 30:42 | -12 | 28 |
| 19 |
|
Balıkesirspor | 28 | 3 | 2 | 23 | 21:54 | -33 | 11 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
