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| 23.02.2022 | 11:00 | Adıyamanspor | - | Afjet Afyonspor | 0:5 (0:1) | |
| 11:00 | Ankaraspor | - | Turgutluspor | 1:1 (0:0) | ||
| 11:00 | Bodrumspor | - | Sivas Belediyespor | 1:0 (0:0) | ||
| 11:00 | Çorum FK | - | Bayburt İl Özel İdare | 0:1 (0:1) | ||
| 11:00 | 1461 Trabzon FK | - | Sakaryaspor | 0:1 (0:0) | ||
| 11:00 | Inegölspor | - | Ergene Velimeşe | 1:0 (1:0) | ||
| 11:00 | Niğde Anadolu FK | - | Diyarbekirspor | 2:1 (1:1) | ||
| 11:00 | Sarıyer SK | - | Etimesgut Belediyespor | 2:2 (1:0) | ||
| 11:00 | Somaspor | - | Serik Belediyespor | 2:1 (0:1) | ||
| 11:00 | Vanspor FK | - | Kahramanmaraşspor | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Sakaryaspor | 27 | 18 | 7 | 2 | 53:16 | 37 | 61 |
| 2 |
|
1461 Trabzon FK | 27 | 17 | 7 | 3 | 46:19 | 27 | 58 |
| 3 |
|
Vanspor FK | 27 | 15 | 6 | 6 | 39:32 | 7 | 51 |
| 4 |
|
Bodrumspor | 27 | 15 | 5 | 7 | 41:22 | 19 | 50 |
| 5 |
|
Sivas Belediyespor | 27 | 14 | 7 | 6 | 47:22 | 25 | 49 |
| 6 |
|
Afjet Afyonspor | 27 | 13 | 8 | 6 | 54:30 | 24 | 47 |
| 7 |
|
Bayburt İl Özel İdare | 27 | 14 | 5 | 8 | 37:26 | 11 | 47 |
| 8 |
|
Somaspor | 27 | 13 | 6 | 8 | 43:36 | 7 | 45 |
| 9 |
|
Çorum FK | 27 | 12 | 7 | 8 | 38:25 | 13 | 43 |
| 10 |
|
Inegölspor | 27 | 12 | 4 | 11 | 34:36 | -2 | 40 |
| 11 |
|
Ankaraspor | 27 | 10 | 9 | 8 | 42:30 | 12 | 39 |
| 12 |
|
Etimesgut Belediyespor | 27 | 8 | 9 | 10 | 33:39 | -6 | 33 |
| 13 |
|
Serik Belediyespor | 27 | 9 | 4 | 14 | 32:38 | -6 | 31 |
| 14 |
|
Sarıyer SK | 27 | 8 | 6 | 13 | 32:39 | -7 | 30 |
| 15 |
|
Diyarbekirspor | 27 | 8 | 4 | 15 | 27:33 | -6 | 28 |
| 16 |
|
Adıyamanspor | 27 | 9 | 1 | 17 | 36:53 | -17 | 28 |
| 17 |
|
Turgutluspor | 27 | 5 | 10 | 12 | 23:44 | -21 | 25 |
| 18 |
|
Ergene Velimeşe | 27 | 6 | 3 | 18 | 27:55 | -28 | 21 |
| 19 |
|
Kahramanmaraşspor | 27 | 3 | 5 | 19 | 19:63 | -44 | 14 |
| 20 |
|
Niğde Anadolu FK | 27 | 2 | 5 | 20 | 21:66 | -45 | 11 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
