| Gruppe E Nord | 07.09.2021 | Doncaster Rovers | - | Rotherham United | 0:6 | ||||
| Gruppe E Nord | 05.10.2021 | Rotherham United | - | Scunthorpe United | 4:1 | ||||
| Gruppe E Nord | 26.10.2021 | Rotherham United | - | Manchester City U23 | 5:0 |  |
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| 2. Runde | 30.11.2021 | Rotherham United | - | Port Vale FC | 5:3 i.E. | ||||
| Achtelfinale | 04.01.2022 | Crewe Alexandra | - | Rotherham United | 2:4 | |
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| Viertelfinale | 25.01.2022 | Rotherham United | - | Cambridge United | 7:6 i.E. |
England