| Gruppe A | 26.11.2020 | CFR Cluj | - | AS Roma | 0:2 | ||||
| Gruppe A | 03.12.2020 | AS Roma | - | BSC Young Boys | 3:1 |  |
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| Achtelfinale | 18.03.2021 | Shakhtar Donetsk | - | AS Roma | 1:2 | ||||
| Viertelfinale | 08.04.2021 | AFC Ajax | - | AS Roma | 1:2 | |
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| Viertelfinale | 15.04.2021 | AS Roma | - | AFC Ajax | 1:1 |
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