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| 27.11.2021 | 13:45 | Panserraikos | - | Apollon Lárissa | 1:0 (1:0) | |
| 28.11.2021 | 13:45 | AEP Iraklis FC | - | AE Lárissa | 1:1 (0:0) | |
| 13:45 | Veria FC | - | AO Trikala | 1:0 (0:0) | ||
| 13:45 | Apollon Pontou | - | PAOK Saloniki II | 0:3 (0:2) | ||
| 13:45 | Anagennisi Karditsa | - | Olympiakos Volou | 4:0 (1:0) | ||
| 13:45 | Pierikos Katerini | - | Niki Volou FC | 0:3 (0:1) | ||
| 13:45 | Xanthi FC | - | Almopos Arideas | 2:0 (0:0) | ||
| 13:45 | Thesprotos | - | AO Kavala | 7:0 (4:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Veria FC | 5 | 4 | 1 | 0 | 9:3 | 6 | 13 |
| 2 |
|
Xanthi FC | 4 | 3 | 1 | 0 | 10:1 | 9 | 10 |
| 3 |
|
Anagennisi Karditsa | 5 | 3 | 0 | 2 | 10:4 | 6 | 9 |
| 4 |
|
Niki Volou FC | 5 | 2 | 3 | 0 | 6:2 | 4 | 9 |
| 5 |
|
Olympiakos Piraeus II | 4 | 2 | 2 | 0 | 6:3 | 3 | 8 |
| 6 |
|
AE Lárissa | 4 | 2 | 1 | 1 | 5:2 | 3 | 7 |
| 7 |
|
Thesprotos | 4 | 2 | 0 | 2 | 8:2 | 6 | 6 |
| 8 |
|
Panserraikos | 5 | 1 | 3 | 1 | 5:6 | -1 | 6 |
| 9 |
|
Almopos Arideas | 5 | 2 | 0 | 3 | 5:8 | -3 | 6 |
| 10 |
|
PAOK Saloniki II | 5 | 1 | 2 | 2 | 6:6 | 0 | 5 |
| 11 |
|
AEP Iraklis FC | 5 | 0 | 5 | 0 | 2:2 | 0 | 5 |
| 12 |
|
Olympiakos Volou | 5 | 1 | 2 | 2 | 6:12 | -6 | 5 |
| 13 |
|
Apollon Pontou | 5 | 1 | 1 | 3 | 9:8 | 1 | 4 |
|
Pierikos Katerini | 5 | 1 | 1 | 3 | 9:8 | 1 | 4 | |
| 15 |
|
AO Trikala | 5 | 0 | 4 | 1 | 4:5 | -1 | 4 |
| 16 |
|
AO Kavala | 5 | 1 | 0 | 4 | 3:28 | -25 | 3 |
| 17 |
|
Apollon Lárissa | 4 | 0 | 2 | 2 | 5:8 | -3 | 2 |
| Playoffs | |
| Abstieg |
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# Apollon Lárissa wurde mit einem Abzug von 6 Punkten belegt. |
