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| 12.02.2022 | 15:00 | Lazio Roma | - | Bologna FC | 3:0 (1:0) | |
| 18:00 | SSC Napoli | - | Inter | 1:1 (1:0) | ||
| 20:45 | Torino FC | - | Venezia FC | 1:2 (1:1) | ||
| 13.02.2022 | 12:30 | AC Milan | - | Sampdoria | 1:0 (1:0) | |
| 15:00 | Genoa CFC | - | US Salernitana 1919 | 1:1 (1:1) | ||
| 15:00 | Empoli FC | - | Cagliari Calcio | 1:1 (1:0) | ||
| 15:00 | Hellas Verona | - | Udinese Calcio | 4:0 (2:0) | ||
| 18:00 | Sassuolo Calcio | - | AS Roma | 2:2 (0:1) | ||
| 20:45 | Atalanta | - | Juventus | 1:1 (0:0) | ||
| 14.02.2022 | 20:45 | Spezia Calcio | - | ACF Fiorentina | 1:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
AC Milan | 25 | 17 | 4 | 4 | 50:26 | 24 | 55 |
| 2 |
|
Inter | 25 | 16 | 6 | 3 | 56:22 | 34 | 54 |
| 3 |
|
SSC Napoli | 25 | 16 | 5 | 4 | 46:17 | 29 | 53 |
| 4 |
|
Juventus | 25 | 13 | 7 | 5 | 37:22 | 15 | 46 |
| 5 |
|
Atalanta | 25 | 12 | 9 | 4 | 50:33 | 17 | 45 |
| 6 |
|
Lazio Roma | 25 | 12 | 6 | 7 | 52:39 | 13 | 42 |
| 7 |
|
AS Roma | 25 | 12 | 4 | 9 | 42:32 | 10 | 40 |
| 8 |
|
ACF Fiorentina | 25 | 12 | 3 | 10 | 43:38 | 5 | 39 |
| 9 |
|
Hellas Verona | 25 | 10 | 6 | 9 | 47:40 | 7 | 36 |
| 10 |
|
Torino FC | 25 | 9 | 6 | 10 | 35:29 | 6 | 33 |
| 11 |
|
Empoli FC | 25 | 8 | 7 | 10 | 38:48 | -10 | 31 |
| 12 |
|
Bologna FC | 25 | 9 | 4 | 12 | 31:41 | -10 | 31 |
| 13 |
|
Sassuolo Calcio | 25 | 7 | 9 | 9 | 41:44 | -3 | 30 |
| 14 |
|
Udinese Calcio | 25 | 6 | 9 | 10 | 34:41 | -7 | 27 |
| 15 |
|
Spezia Calcio | 25 | 7 | 5 | 13 | 27:46 | -19 | 26 |
| 16 |
|
Sampdoria | 25 | 6 | 5 | 14 | 33:42 | -9 | 23 |
| 17 |
|
Cagliari Calcio | 25 | 4 | 9 | 12 | 25:46 | -21 | 21 |
| 18 |
|
Venezia FC | 25 | 5 | 6 | 14 | 23:45 | -22 | 21 |
| 19 |
|
US Salernitana 1919 | 25 | 5 | 4 | 16 | 20:54 | -34 | 19 |
| 20 |
|
Genoa CFC | 25 | 1 | 12 | 12 | 21:46 | -25 | 15 |
| Champions League | |
| Europa League | |
| Europa Conference League Quali. | |
| Abstieg |
