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| 16.04.2022 | Palermo FC | - | Calcio Catania | n.gesp. | ||
| 17:30 | ACR Messina | - | FC Turris | 1:2 (0:1) | ||
| 17:30 | Fidelis Andria | - | Monterosi FC | 0:0 (0:0) | ||
| 17:30 | Paganese Calcio | - | AZ Picerno | 2:3 (0:2) | ||
| 17:30 | Potenza | - | SS Juve Stabia | 1:1 (1:0) | ||
| 17:30 | Taranto FC | - | SSC Bari | 0:0 (0:0) | ||
| 17:30 | US Avellino | - | Vibonese Calcio | 3:1 (1:0) | ||
| 17:30 | US Catanzaro | - | Campobasso | 3:0 (1:0) | ||
| 17:30 | Latina Calcio | - | SS Monopoli 1966 | 0:0 (0:0) | ||
| 17:30 | Virtus Francavilla | - | Foggia Calcio | 2:2 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SSC Bari | 35 | 22 | 9 | 4 | 52:24 | 28 | 75 |
| 2 |
|
US Catanzaro | 35 | 18 | 10 | 7 | 54:26 | 28 | 64 |
| 3 |
|
US Avellino | 35 | 17 | 13 | 5 | 45:24 | 21 | 64 |
| 4 |
|
Palermo FC | 35 | 17 | 12 | 6 | 62:33 | 29 | 63 |
| 5 |
|
Virtus Francavilla | 35 | 16 | 8 | 11 | 48:34 | 14 | 56 |
| 6 |
|
SS Monopoli 1966 | 35 | 16 | 8 | 11 | 36:30 | 6 | 56 |
| 7 |
|
Foggia Calcio | 35 | 12 | 15 | 8 | 60:51 | 9 | 51 |
| 8 |
|
Monterosi FC | 35 | 13 | 12 | 10 | 40:37 | 3 | 51 |
| 9 |
|
FC Turris | 35 | 15 | 4 | 16 | 48:47 | 1 | 49 |
| 10 |
|
AZ Picerno | 35 | 14 | 7 | 14 | 39:43 | -4 | 49 |
| 11 |
|
SS Juve Stabia | 35 | 12 | 12 | 11 | 40:36 | 4 | 46 |
| 12 |
|
Campobasso | 35 | 11 | 10 | 14 | 50:61 | -11 | 43 |
| 13 |
|
Latina Calcio | 35 | 11 | 9 | 15 | 36:42 | -6 | 42 |
| 14 |
|
ACR Messina | 36 | 10 | 9 | 17 | 40:57 | -17 | 39 |
| 15 |
|
Taranto FC | 35 | 8 | 14 | 13 | 29:38 | -9 | 38 |
| 16 |
|
Potenza | 35 | 8 | 12 | 15 | 36:50 | -14 | 36 |
| 17 |
|
Fidelis Andria | 35 | 6 | 12 | 17 | 25:43 | -18 | 30 |
| 18 |
|
Paganese Calcio | 35 | 6 | 8 | 21 | 34:65 | -31 | 26 |
| 19 |
|
Vibonese Calcio | 35 | 3 | 12 | 20 | 24:57 | -33 | 21 |
| 20 |
|
Calcio Catania | 0 | 0 | 0 | 0 | 0:0 | 0 | 0 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
|
# Calcio Catania ging im Frühjahr 2022 bankrott und wurde vom professionellen Fußball ausgeschlossen. Alle Saisonspiele des Vereins wurden annulliert. |
