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| 15.03.2019 | 17:00 | Pumas UNAM II | - | Sporting Canamy | 5:0 (1:0) | |
| 17:00 | CF América II | - | Tuzos de la UAZ | 0:1 (0:0) | ||
| 16.03.2019 | 01:00 | Tecos Fútbol Club | - | Murciélagos FC | 2:2 (0:1) | |
| 02:30 | Atlético Reynosa | - | Cimarrones de Sonora II | 3:0 (0:0) | ||
| 03:00 | Coras de Nayarit | - | Tepatitlán | 4:2 (1:0) | ||
| 03:00 | Alacranes de Durango | - | Gavilanes de Matamoros | 1:1 (0:1) | ||
| 03:10 | Pacific F. C. | - | Correcaminos UAT II | 2:4 (0:3) | ||
| 18:00 | Coyotes de Tlaxcala | - | Yalmakan FC | 2:1 (0:0) | ||
| 19:15 | Deportivo Toluca II | - | Cocodrilos de Tabasco | 2:0 (1:0) | ||
| 21:00 | Inter Playa | - | Club Irapuato | 0:0 (0:0) | ||
| 22:00 | Tuxtla FC | - | Reboceros de La Piedad | 0:0 (0:0) | ||
| 22:00 | Albinegros Orizaba | - | Real Zamora | 3:0 (0:0) | ||
| 23:00 | Dorados UACH | - | Leones Negros II | 3:1 (1:1) | ||
| 23:00 | Loros UCOL | - | Monarcas Morelia II | 3:1 (1:1) | ||
| 23:00 | Pioneros de Cancún | - | Cruz Azul Hidalgo | 0:2 (0:0) | ||
| 17.03.2019 | 19:00 | Deportivo Guadalajara II | - | Club Necaxa II | 1:1 (1:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Club Irapuato | 25 | 18 | 5 | 2 | 44:14 | 30 | 63 |
| 2 |
|
Loros UCOL | 25 | 14 | 4 | 7 | 63:29 | 34 | 52 |
| 3 |
|
Deportivo Guadalajara II | 25 | 13 | 9 | 3 | 37:24 | 13 | 52 |
| 4 |
|
Pumas UNAM II | 25 | 13 | 5 | 7 | 41:26 | 15 | 47 |
| 5 |
|
Tepatitlán | 25 | 13 | 6 | 6 | 44:34 | 10 | 47 |
| 6 |
|
Club Necaxa II | 25 | 12 | 8 | 5 | 30:24 | 6 | 47 |
| 7 |
|
Murciélagos FC | 25 | 12 | 6 | 7 | 44:27 | 17 | 45 |
| 8 |
|
Atlético Reynosa | 25 | 11 | 8 | 6 | 34:18 | 16 | 45 |
| 9 |
|
Tuxtla FC | 25 | 12 | 5 | 8 | 37:24 | 13 | 43 |
| 10 |
|
Tuzos de la UAZ | 25 | 11 | 8 | 6 | 36:30 | 6 | 43 |
| 11 |
|
Dorados UACH | 25 | 11 | 6 | 8 | 30:25 | 5 | 43 |
| 12 |
|
Coras de Nayarit | 25 | 11 | 7 | 7 | 35:28 | 7 | 42 |
| 13 |
|
Deportivo Toluca II | 25 | 11 | 7 | 7 | 37:31 | 6 | 42 |
| 14 |
|
Cruz Azul Hidalgo | 25 | 10 | 6 | 9 | 30:27 | 3 | 40 |
| 15 |
|
Gavilanes de Matamoros | 25 | 10 | 7 | 8 | 35:29 | 6 | 39 |
| 16 |
|
Real Zamora | 25 | 11 | 4 | 10 | 33:34 | -1 | 39 |
| 17 |
|
Inter Playa | 25 | 9 | 8 | 8 | 28:26 | 2 | 37 |
| 18 |
|
Correcaminos UAT II | 25 | 9 | 7 | 9 | 34:37 | -3 | 37 |
| 19 |
|
Coyotes de Tlaxcala | 25 | 7 | 12 | 6 | 31:28 | 3 | 35 |
| 20 |
|
Monarcas Morelia II | 25 | 8 | 9 | 8 | 42:30 | 12 | 34 |
| 21 |
|
Albinegros Orizaba | 25 | 9 | 5 | 11 | 22:30 | -8 | 33 |
| 22 |
|
Reboceros de La Piedad | 25 | 6 | 9 | 10 | 29:35 | -6 | 31 |
| 23 |
|
Cocodrilos de Tabasco | 25 | 5 | 10 | 10 | 21:28 | -7 | 28 |
| 24 |
|
Tecos Fútbol Club | 25 | 5 | 8 | 12 | 34:42 | -8 | 28 |
| 25 |
|
Leones Negros II | 25 | 7 | 6 | 12 | 32:42 | -10 | 28 |
| 26 |
|
Pioneros de Cancún | 25 | 4 | 11 | 10 | 23:32 | -9 | 25 |
| 27 |
|
Sporting Canamy | 25 | 6 | 6 | 13 | 26:49 | -23 | 25 |
| 28 |
|
CF América II | 25 | 4 | 10 | 11 | 26:39 | -13 | 24 |
| 29 |
|
Yalmakan FC | 25 | 4 | 9 | 12 | 26:37 | -11 | 23 |
| 30 |
|
Alacranes de Durango | 25 | 4 | 10 | 11 | 20:33 | -13 | 23 |
| 31 |
|
Pacific F. C. | 25 | 3 | 6 | 16 | 25:58 | -33 | 17 |
| 32 |
|
Cimarrones de Sonora II | 25 | 2 | 3 | 20 | 10:69 | -59 | 9 |
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| Playoffs | |
| Playoffs | |
| Abstieg |
