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| 19.03.2022 | 16:00 | Gallos Blancos | - | Cruz Azul | 1:1 (1:0) | |
| 16:00 | Deportivo Guadalajara | - | Club Tijuana | 2:0 (0:0) | ||
| 16:00 | Santos Laguna | - | Atlético San Luis | 2:1 (1:1) | ||
| 16:00 | Pumas UNAM | - | CF América | 1:0 (1:0) | ||
| 16:00 | UANL Tigres | - | Mazatlán FC | 0:0 (0:0) | ||
| 16:00 | CF Monterrey | - | Atlas Guadalajara | 1:1 (1:1) | ||
| 18:30 | Club Necaxa | - | Deportivo Toluca | 1:0 (1:0) | ||
| 19:00 | Puebla FC | - | CF Pachuca | 0:4 (0:2) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Cruz Azul | 10 | 6 | 2 | 2 | 22:13 | 9 | 20 |
| 2 |
|
Pumas UNAM | 10 | 6 | 1 | 3 | 15:8 | 7 | 19 |
| 3 |
|
CF América | 10 | 5 | 1 | 4 | 14:12 | 2 | 16 |
| 4 |
|
Deportivo Toluca | 10 | 4 | 2 | 4 | 22:17 | 5 | 14 |
| 5 |
|
Puebla FC | 10 | 4 | 2 | 4 | 17:14 | 3 | 14 |
| 6 |
|
CF Pachuca | 10 | 3 | 4 | 3 | 22:21 | 1 | 13 |
| 7 |
|
Club Necaxa | 9 | 3 | 4 | 2 | 12:15 | -3 | 13 |
| 8 |
|
FC Juárez | 9 | 2 | 1 | 6 | 11:22 | -11 | 7 |
| 9 |
|
Gallos Blancos | 10 | 1 | 3 | 6 | 7:20 | -13 | 6 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 10 | 7 | 2 | 1 | 23:9 | 14 | 23 |
| 2 |
|
Atlas Guadalajara | 10 | 5 | 3 | 2 | 22:14 | 8 | 18 |
| 3 |
|
Santos Laguna | 10 | 5 | 2 | 3 | 15:11 | 4 | 17 |
| 4 |
|
UANL Tigres | 10 | 4 | 4 | 2 | 12:11 | 1 | 16 |
| 5 |
|
CF Monterrey | 10 | 2 | 5 | 3 | 15:13 | 2 | 11 |
| 6 |
|
Club León | 9 | 3 | 2 | 4 | 11:13 | -2 | 11 |
| 7 |
|
Club Tijuana | 9 | 3 | 1 | 5 | 7:14 | -7 | 10 |
| 8 |
|
Mazatlán FC | 10 | 2 | 3 | 5 | 12:22 | -10 | 9 |
| 9 |
|
Atlético San Luis | 10 | 1 | 2 | 7 | 8:18 | -10 | 5 |
| Playoffs | |
| Playoffs |
