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| 08.10.2022 | 16:00 | Gallos Blancos | - | Cruz Azul | 0:4 (0:2) | |
| 16:00 | Santos Laguna | - | Atlético San Luis | 4:0 (3:0) | ||
| 16:00 | Pumas UNAM | - | FC Juárez | 1:1 (1:1) | ||
| 16:00 | UANL Tigres | - | Club Tijuana | 4:1 (1:0) | ||
| 16:00 | Atlas Guadalajara | - | CF Monterrey | 2:2 (0:0) | ||
| 16:00 | Club León | - | Deportivo Guadalajara | 1:2 (1:0) | ||
| 16:00 | Club Necaxa | - | CF América | 4:2 (4:1) | ||
| 17:30 | Deportivo Toluca | - | Puebla FC | 3:1 (1:0) |
| 1 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Toluca | 14 | 8 | 2 | 4 | 38:25 | 13 | 26 |
| 2 |
|
Club Necaxa | 14 | 7 | 3 | 4 | 35:22 | 13 | 24 |
| 3 |
|
Cruz Azul | 14 | 6 | 4 | 4 | 32:22 | 10 | 22 |
| 4 |
|
CF América | 14 | 6 | 4 | 4 | 27:25 | 2 | 22 |
| 5 |
|
Gallos Blancos | 15 | 6 | 2 | 7 | 18:29 | -11 | 20 |
| 6 |
|
CF Pachuca | 14 | 6 | 1 | 7 | 22:23 | -1 | 19 |
| 7 |
|
Pumas UNAM | 14 | 5 | 4 | 5 | 17:20 | -3 | 19 |
| 8 |
|
FC Juárez | 15 | 4 | 6 | 5 | 21:25 | -4 | 18 |
| 9 |
|
Puebla FC | 14 | 2 | 2 | 10 | 18:37 | -19 | 8 |
| 2 | |||||||||
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 14 | 10 | 3 | 1 | 29:14 | 15 | 33 |
| 2 |
|
Santos Laguna | 14 | 10 | 1 | 3 | 28:11 | 17 | 31 |
| 3 |
|
CF Monterrey | 14 | 8 | 2 | 4 | 33:18 | 15 | 26 |
| 4 |
|
Mazatlán FC | 14 | 7 | 1 | 6 | 18:23 | -5 | 22 |
| 5 |
|
Atlas Guadalajara | 14 | 6 | 3 | 5 | 20:16 | 4 | 21 |
| 6 |
|
UANL Tigres | 14 | 6 | 1 | 7 | 18:18 | 0 | 19 |
| 7 |
|
Atlético San Luis | 15 | 4 | 3 | 8 | 21:30 | -9 | 15 |
| 8 |
|
Club Tijuana | 14 | 4 | 2 | 8 | 16:26 | -10 | 14 |
| 9 |
|
Club León | 15 | 0 | 2 | 13 | 19:46 | -27 | 2 |
| Playoffs | |
| Playoffs |
