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| 11.05.2001 | 20:00 | VVV | - | ADO Den Haag | 1:1 (0:0) | |
| 12.05.2001 | 20:00 | BV Veendam | - | FC Den Bosch | 3:1 (2:0) | |
| 20:00 | Heracles Almelo | - | Go Ahead Eagles | 0:1 (0:1) | ||
| 20:00 | FC Zwolle | - | SBV Excelsior | 2:1 (0:1) | ||
| 20:00 | Dordrecht '90 | - | SC Cambuur | 1:2 (1:0) | ||
| 20:00 | SBV Eindhoven | - | FC Volendam | 3:1 (1:0) | ||
| 20:00 | Helmond Sport | - | BV Emmen | 0:0 (0:0) | ||
| 20:00 | TOP Oss | - | HFC Haarlem | 1:4 (1:1) | ||
| 20:00 | Telstar | - | MVV | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC Den Bosch | 32 | 22 | 5 | 5 | 62:25 | 37 | 71 |
| 2 |
|
SBV Excelsior | 32 | 18 | 6 | 8 | 79:61 | 18 | 60 |
| 3 |
|
FC Zwolle | 32 | 16 | 10 | 6 | 68:40 | 28 | 58 |
| 4 |
|
SC Cambuur | 32 | 15 | 9 | 8 | 53:43 | 10 | 54 |
| 5 |
|
Go Ahead Eagles | 32 | 16 | 4 | 12 | 59:59 | 0 | 52 |
| 6 |
|
Telstar | 32 | 14 | 7 | 11 | 45:47 | -2 | 49 |
| 7 |
|
FC Volendam | 32 | 14 | 5 | 13 | 49:46 | 3 | 47 |
| 8 |
|
Helmond Sport | 32 | 12 | 9 | 11 | 64:46 | 18 | 45 |
| 9 |
|
SBV Eindhoven | 32 | 12 | 8 | 12 | 56:54 | 2 | 44 |
| 10 |
|
TOP Oss | 32 | 13 | 2 | 17 | 53:63 | -10 | 41 |
| 11 |
|
BV Veendam | 32 | 11 | 6 | 15 | 51:63 | -12 | 39 |
| 12 |
|
Heracles Almelo | 32 | 10 | 9 | 13 | 37:50 | -13 | 39 |
| 13 |
|
BV Emmen | 32 | 10 | 8 | 14 | 50:58 | -8 | 38 |
| 14 |
|
Dordrecht '90 | 32 | 9 | 10 | 13 | 56:57 | -1 | 37 |
| 15 |
|
MVV | 32 | 11 | 4 | 17 | 41:54 | -13 | 37 |
| 16 |
|
HFC Haarlem | 32 | 8 | 9 | 15 | 45:59 | -14 | 33 |
| 17 |
|
ADO Den Haag | 32 | 8 | 9 | 15 | 48:67 | -19 | 33 |
| 18 |
|
VVV | 32 | 7 | 4 | 21 | 35:59 | -24 | 25 |
