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| 14.01.2022 | 18:00 | Beşiktaş | - | Gaziantep FK | 1:0 (0:0) | |
| 18:00 | Yeni Malatyaspor | - | Göztepe | 1:2 (1:1) | ||
| 15.01.2022 | 11:30 | Adana Demirspor | - | Kayserispor | 1:1 (1:0) | |
| 14:00 | Fatih Karagümrük SK | - | Çaykur Rizespor | 2:0 (1:0) | ||
| 14:00 | Sivasspor | - | Trabzonspor | 1:1 (1:1) | ||
| 17:00 | Antalyaspor | - | Fenerbahçe | 1:1 (0:0) | ||
| 16.01.2022 | 11:30 | Altay Izmir | - | Alanyaspor | 0:2 (0:1) | |
| 14:00 | Giresunspor | - | Kasımpaşa SK | 0:2 (0:1) | ||
| 17:00 | Hatayspor | - | Galatasaray | 4:2 (1:2) | ||
| 22.02.2022 | 18:00 | İstanbul Başakşehir | - | Konyaspor | 2:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 21 | 15 | 5 | 1 | 38:15 | 23 | 50 |
| 2 |
|
Konyaspor | 21 | 11 | 6 | 4 | 33:18 | 15 | 39 |
| 3 |
|
İstanbul Başakşehir | 21 | 11 | 4 | 6 | 32:21 | 11 | 37 |
| 4 |
|
Hatayspor | 21 | 11 | 2 | 8 | 32:28 | 4 | 35 |
| 5 |
|
Adana Demirspor | 21 | 9 | 7 | 5 | 30:24 | 6 | 34 |
| 6 |
|
Fenerbahçe | 21 | 9 | 6 | 6 | 33:26 | 7 | 33 |
| 7 |
|
Beşiktaş | 21 | 9 | 5 | 7 | 33:30 | 3 | 32 |
| 8 |
|
Alanyaspor | 21 | 9 | 5 | 7 | 32:32 | 0 | 32 |
| 9 |
|
Gaziantep FK | 21 | 9 | 4 | 8 | 27:28 | -1 | 31 |
| 10 |
|
Sivasspor | 21 | 7 | 9 | 5 | 28:21 | 7 | 30 |
| 11 |
|
Fatih Karagümrük SK | 21 | 8 | 6 | 7 | 29:30 | -1 | 30 |
| 12 |
|
Kayserispor | 21 | 7 | 7 | 7 | 29:29 | 0 | 28 |
| 13 |
|
Galatasaray | 21 | 7 | 6 | 8 | 26:28 | -2 | 27 |
| 14 |
|
Giresunspor | 21 | 7 | 4 | 10 | 20:21 | -1 | 25 |
| 15 |
|
Antalyaspor | 21 | 6 | 5 | 10 | 22:32 | -10 | 23 |
| 16 |
|
Göztepe | 21 | 5 | 6 | 10 | 24:29 | -5 | 21 |
|
Kasımpaşa SK | 21 | 5 | 6 | 10 | 24:29 | -5 | 21 | |
| 18 |
|
Altay Izmir | 21 | 5 | 3 | 13 | 23:35 | -12 | 18 |
| 19 |
|
Çaykur Rizespor | 21 | 5 | 3 | 13 | 19:38 | -19 | 18 |
| 20 |
|
Yeni Malatyaspor | 21 | 4 | 3 | 14 | 17:37 | -20 | 15 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
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# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
