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| 18.03.2022 | 18:00 | Fatih Karagümrük SK | - | Kayserispor | 3:0 (2:0) | |
| 18:15 | Çaykur Rizespor | - | Trabzonspor | 3:2 (0:0) | ||
| 19.03.2022 | 11:30 | Yeni Malatyaspor | - | Kasımpaşa SK | 0:2 (0:0) | |
| 14:00 | Adana Demirspor | - | İstanbul Başakşehir | 2:1 (1:0) | ||
| 14:00 | Göztepe | - | Alanyaspor | 0:2 (0:0) | ||
| 17:00 | Beşiktaş | - | Hatayspor | 1:1 (1:1) | ||
| 20.03.2022 | 11:30 | Antalyaspor | - | Giresunspor | 4:1 (1:0) | |
| 11:30 | Sivasspor | - | Altay Izmir | 2:1 (0:0) | ||
| 14:00 | Gaziantep FK | - | Galatasaray | 3:1 (1:1) | ||
| 17:00 | Fenerbahçe | - | Konyaspor | 2:1 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Trabzonspor | 30 | 21 | 7 | 2 | 58:26 | 32 | 70 |
| 2 |
|
Konyaspor | 30 | 16 | 7 | 7 | 48:33 | 15 | 55 |
| 3 |
|
Fenerbahçe | 30 | 15 | 8 | 7 | 50:35 | 15 | 53 |
| 4 |
|
Alanyaspor | 30 | 14 | 7 | 9 | 55:47 | 8 | 49 |
| 5 |
|
Adana Demirspor | 30 | 13 | 9 | 8 | 46:32 | 14 | 48 |
| 6 |
|
İstanbul Başakşehir | 30 | 14 | 5 | 11 | 42:31 | 11 | 47 |
| 7 |
|
Hatayspor | 30 | 14 | 5 | 11 | 48:46 | 2 | 47 |
| 8 |
|
Beşiktaş | 30 | 12 | 10 | 8 | 44:39 | 5 | 46 |
| 9 |
|
Fatih Karagümrük SK | 30 | 12 | 7 | 11 | 36:43 | -7 | 43 |
| 10 |
|
Antalyaspor | 30 | 11 | 8 | 11 | 34:36 | -2 | 41 |
| 11 |
|
Sivasspor | 30 | 10 | 10 | 10 | 40:38 | 2 | 40 |
| 12 |
|
Gaziantep FK | 30 | 11 | 7 | 12 | 40:42 | -2 | 40 |
| 13 |
|
Kasımpaşa SK | 30 | 10 | 8 | 12 | 45:43 | 2 | 38 |
| 14 |
|
Kayserispor | 30 | 10 | 8 | 12 | 43:48 | -5 | 38 |
| 15 |
|
Galatasaray | 30 | 10 | 8 | 12 | 40:45 | -5 | 38 |
| 16 |
|
Giresunspor | 30 | 10 | 5 | 15 | 32:37 | -5 | 35 |
| 17 |
|
Altay Izmir | 30 | 8 | 5 | 17 | 31:43 | -12 | 29 |
| 18 |
|
Göztepe | 30 | 7 | 6 | 17 | 36:50 | -14 | 27 |
| 19 |
|
Çaykur Rizespor | 30 | 7 | 5 | 18 | 29:55 | -26 | 26 |
| 20 |
|
Yeni Malatyaspor | 30 | 5 | 5 | 20 | 23:51 | -28 | 20 |
| Champions League | |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Abstieg |
|
# Die Begegnung Gaziantep FK - Yeni Malatyaspor (22. Spieltag) wurde wegen starken Schneefalls in der Halbzeitpause abgebrochen. Die zweite Halbzeit wurde am 23.02.2022 gespielt. |
