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| 05.03.2022 | 11:00 | Stuttgarter Kickers | - | SV Wehen Wiesbaden | 2:1 (1:1) | |
| 06.03.2022 | 11:00 | FSV Frankfurt | - | 1. FSV Mainz 05 | 1:2 (1:1) | |
| 11:00 | FC Ingolstadt 04 | - | TSV 1860 München | 1:0 (1:0) | ||
| 11:00 | Bayern München | - | SV 07 Elversberg | 5:0 (2:0) | ||
| 12:00 | Eintracht Frankfurt | - | SV Darmstadt 98 | 0:1 (0:1) | ||
| 12:30 | 1. FC Nürnberg | - | VfB Stuttgart | 1:2 (0:1) | ||
| 13:00 | SpVgg Greuther Fürth | - | 1899 Hoffenheim | 1:2 (1:2) | ||
| 13:00 | FC Augsburg | - | Karlsruher SC | 0:2 (0:2) | ||
| 14:00 | SC Freiburg | - | 1. FC Kaiserslautern | 5:4 (0:1) | ||
| 26.03.2022 | 14:00 | SSV Reutlingen | - | 1. FC Heidenheim 1846 | 0:2 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
VfB Stuttgart | 16 | 14 | 2 | 0 | 54:14 | 40 | 44 |
| 2 |
|
SpVgg Unterhaching | 16 | 13 | 0 | 3 | 39:23 | 16 | 39 |
| 3 |
|
1. FSV Mainz 05 | 16 | 10 | 4 | 2 | 45:18 | 27 | 34 |
| 4 |
|
1899 Hoffenheim | 16 | 11 | 1 | 4 | 41:24 | 17 | 34 |
| 5 |
|
Bayern München | 16 | 10 | 2 | 4 | 46:21 | 25 | 32 |
| 6 |
|
SC Freiburg | 16 | 10 | 1 | 5 | 45:27 | 18 | 31 |
| 7 |
|
FC Augsburg | 16 | 9 | 2 | 5 | 35:26 | 9 | 29 |
| 8 |
|
SpVgg Greuther Fürth | 16 | 8 | 3 | 5 | 23:20 | 3 | 27 |
| 9 |
|
SV Darmstadt 98 | 17 | 9 | 0 | 8 | 30:34 | -4 | 27 |
| 10 |
|
1. FC Nürnberg | 17 | 8 | 2 | 7 | 44:27 | 17 | 26 |
| 11 |
|
FSV Frankfurt | 17 | 6 | 2 | 9 | 21:26 | -5 | 20 |
| 12 |
|
TSV 1860 München | 16 | 6 | 2 | 8 | 17:22 | -5 | 20 |
| 13 |
|
Karlsruher SC | 16 | 5 | 4 | 7 | 26:25 | 1 | 19 |
| 14 |
|
Eintracht Frankfurt | 16 | 5 | 4 | 7 | 22:26 | -4 | 19 |
| 15 |
|
1. FC Heidenheim 1846 | 16 | 5 | 4 | 7 | 29:38 | -9 | 19 |
| 16 |
|
Stuttgarter Kickers | 16 | 6 | 1 | 9 | 23:32 | -9 | 19 |
| 17 |
|
1. FC Kaiserslautern | 17 | 5 | 2 | 10 | 38:41 | -3 | 17 |
| 18 |
|
FC Ingolstadt 04 | 16 | 3 | 4 | 9 | 16:44 | -28 | 13 |
| 19 |
|
SV Wehen Wiesbaden | 16 | 3 | 1 | 12 | 17:43 | -26 | 10 |
| 20 |
|
SV 07 Elversberg | 16 | 2 | 1 | 13 | 8:49 | -41 | 7 |
| 21 |
|
SSV Reutlingen | 16 | 0 | 2 | 14 | 11:50 | -39 | 2 |
| Playoffs | |
| Abstieg |
