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| 12.11.2021 | 19:00 | ATSV Erlangen | - | DJK Gebenbach | 1:1 (1:0) | |
| 13.11.2021 | 14:00 | Eintracht Bamberg | - | SV Seligenporten | 5:0 (3:0) | |
| 14:00 | TSV Karlburg | - | TSV Abtswind | 0:2 (0:0) | ||
| 14:00 | Vatan Spor Aschaffenburg | - | ASV Cham | 2:1 (0:0) | ||
| 14:00 | DJK Vilzing | - | Würzburger FV | 1:1 (0:1) | ||
| 14.11.2021 | 14:00 | DJK Ammerthal | - | SpVgg Ansbach | 4:3 (2:2) | |
| 15:00 | DJK Bamberg | - | SpVgg Bayern Hof | 4:3 (3:0) | ||
| 06.04.2022 | 18:00 | 1. FC Sand | - | 1. SC Feucht | 1:2 (1:1) | |
| 18:00 | ASV Neumarkt | - | TSV Großbardorf | 0:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Eintracht Bamberg | 20 | 15 | 3 | 2 | 57:12 | 45 | 48 |
| 2 |
|
DJK Vilzing | 20 | 14 | 2 | 4 | 43:20 | 23 | 44 |
| 3 |
|
SpVgg Ansbach | 20 | 14 | 2 | 4 | 45:23 | 22 | 44 |
| 4 |
|
ATSV Erlangen | 20 | 13 | 3 | 4 | 44:20 | 24 | 42 |
| 5 |
|
DJK Ammerthal | 20 | 13 | 2 | 5 | 49:30 | 19 | 41 |
| 6 |
|
ASV Neumarkt | 20 | 12 | 3 | 5 | 41:25 | 16 | 39 |
| 7 |
|
1. SC Feucht | 20 | 9 | 5 | 6 | 31:24 | 7 | 32 |
| 8 |
|
DJK Bamberg | 20 | 10 | 2 | 8 | 34:34 | 0 | 32 |
| 9 |
|
TSV Abtswind | 20 | 9 | 2 | 9 | 30:28 | 2 | 29 |
| 10 |
|
TSV Großbardorf | 20 | 8 | 3 | 9 | 26:36 | -10 | 27 |
| 11 |
|
DJK Gebenbach | 20 | 7 | 4 | 9 | 43:42 | 1 | 25 |
| 12 |
|
SpVgg Bayern Hof | 20 | 5 | 4 | 11 | 36:47 | -11 | 19 |
| 13 |
|
TSV Karlburg | 20 | 3 | 10 | 7 | 14:26 | -12 | 19 |
| 14 |
|
Würzburger FV | 20 | 5 | 3 | 12 | 21:42 | -21 | 18 |
| 15 |
|
Vatan Spor Aschaffenburg | 20 | 3 | 5 | 12 | 21:43 | -22 | 14 |
| 16 |
|
1. FC Sand | 20 | 3 | 5 | 12 | 16:41 | -25 | 14 |
| 17 |
|
SV Seligenporten | 20 | 3 | 3 | 14 | 24:52 | -28 | 12 |
| 18 |
|
ASV Cham | 20 | 2 | 3 | 15 | 22:52 | -30 | 9 |
| Aufstieg | |
| Playoffs | |
| Relegation | |
| Abstieg |
