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| H | Boca Juniors | - | Atlas Guadalajara | 2:2 (1:1) | ||
| R | Atlas Guadalajara | - | Boca Juniors | 0:3 (0:3) | ||
| H: 15.05.2008 00:15 | R: 22.05.2008 00:25 | Sieger: Boca Juniors | ||||
| H | São Paulo FC | - | Fluminense RJ | 1:0 (1:0) | ||
| R | Fluminense RJ | - | São Paulo FC | 3:1 (1:0) | ||
| H: 15.05.2008 02:50 | R: 22.05.2008 02:50 | Sieger: Fluminense RJ | ||||
| H | San Lorenzo | - | LDU Quito | 1:1 (1:1) | ||
| R | LDU Quito | - | San Lorenzo | 5:3 (1:0, 1:1, 1:1) i.E. | ||
| H: 16.05.2008 00:00 | R: 23.05.2008 00:20 | Sieger: LDU Quito | ||||
| H | CF América | - | Santos FC | 2:0 (1:0) | ||
| R | Santos FC | - | CF América | 1:0 (0:0) | ||
| H: 16.05.2008 02:20 | R: 23.05.2008 02:50 | Sieger: CF América | ||||
