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| 29.04.2022 | 22:00 | UD Las Palmas | - | Málaga CF | 2:1 (1:0) | |
| 30.04.2022 | 16:00 | Real Oviedo | - | CD Mirandés | 3:0 (1:0) | |
| 18:15 | SD Eibar | - | Real Zaragoza | 2:0 (0:0) | ||
| 20:30 | Burgos CF | - | UD Almería | 0:2 (0:2) | ||
| 01.05.2022 | 14:00 | SD Amorebieta | - | CF Fuenlabrada | 2:1 (1:0) | |
| 16:00 | AD Alcorcón | - | Girona FC | 0:1 (0:1) | ||
| 16:00 | Sporting Gijón | - | UD Ibiza | 0:1 (0:1) | ||
| 18:15 | CD Lugo | - | CD Tenerife | 0:2 (0:0) | ||
| 18:15 | SD Ponferradina | - | FC Cartagena | 4:2 (3:2) | ||
| 02.05.2022 | 18:30 | CD Leganés | - | SD Huesca | 2:1 (1:1) | |
| 21:00 | Real Valladolid | - | Real Sociedad B | 1:2 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
SD Eibar | 38 | 21 | 11 | 6 | 56:40 | 16 | 74 |
| 2 |
|
UD Almería | 38 | 22 | 7 | 9 | 60:32 | 28 | 73 |
| 3 |
|
Real Valladolid | 38 | 20 | 9 | 9 | 62:42 | 20 | 69 |
| 4 |
|
CD Tenerife | 38 | 19 | 9 | 10 | 51:31 | 20 | 66 |
| 5 |
|
Girona FC | 38 | 19 | 7 | 12 | 54:39 | 15 | 64 |
| 6 |
|
Real Oviedo | 38 | 16 | 15 | 7 | 50:34 | 16 | 63 |
| 7 |
|
SD Ponferradina | 38 | 16 | 12 | 10 | 54:48 | 6 | 60 |
| 8 |
|
UD Las Palmas | 38 | 15 | 13 | 10 | 51:46 | 5 | 58 |
| 9 |
|
FC Cartagena | 38 | 16 | 4 | 18 | 55:55 | 0 | 52 |
| 10 |
|
UD Ibiza | 38 | 12 | 15 | 11 | 49:49 | 0 | 51 |
| 11 |
|
Burgos CF | 38 | 14 | 8 | 16 | 38:37 | 1 | 50 |
| 12 |
|
SD Huesca | 38 | 12 | 14 | 12 | 45:37 | 8 | 50 |
| 13 |
|
CD Leganés | 38 | 12 | 13 | 13 | 43:46 | -3 | 49 |
| 14 |
|
Real Zaragoza | 38 | 10 | 19 | 9 | 33:39 | -6 | 49 |
| 15 |
|
CD Lugo | 38 | 9 | 19 | 10 | 43:47 | -4 | 46 |
| 16 |
|
CD Mirandés | 38 | 13 | 7 | 18 | 49:58 | -9 | 46 |
| 17 |
|
Sporting Gijón | 38 | 10 | 11 | 17 | 40:45 | -5 | 41 |
| 18 |
|
Málaga CF | 38 | 10 | 11 | 17 | 34:55 | -21 | 41 |
| 19 |
|
SD Amorebieta | 38 | 7 | 16 | 15 | 42:55 | -13 | 37 |
| 20 |
|
Real Sociedad B | 38 | 9 | 10 | 19 | 38:53 | -15 | 37 |
| 21 |
|
CF Fuenlabrada | 38 | 5 | 14 | 19 | 34:57 | -23 | 29 |
| 22 |
|
AD Alcorcón | 38 | 4 | 10 | 24 | 32:68 | -36 | 22 |
| Aufstieg | |
| Playoffs | |
| Abstieg |
