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| 10.04.2022 | 15:00 | Borussia Freialdenhoven | - | Spvg Wesseling-Urfeld | 3:1 (2:1) | |
| 15:00 | FC Hürth | - | BC Viktoria Glesch-Paffendorf | 2:1 (1:1) | ||
| 15:00 | FC Hennef 05 | - | FC Pesch 1956 | 6:0 (5:0) | ||
| 15:00 | 1. FC Düren | - | SV Deutz 05 | 3:1 (1:0) | ||
| 15:00 | SV Bergisch Gladbach 09 | - | Viktoria Arnoldsweiler | 2:1 (1:1) | ||
| 15:30 | Fortuna Köln II | - | VfL Alfter | 1:1 (1:0) | ||
| 15:30 | Blau-Weiß Friesdorf | - | Siegburger SV 04 | 1:1 (1:1) | ||
| 15:30 | VfL 08 Vichttal | - | SV 1914 Eilendorf | 2:2 (0:0) | ||
| 15:30 | SpVg Frechen 20 | - | SV Breinig | 6:1 (2:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
1. FC Düren | 25 | 20 | 4 | 1 | 70:16 | 54 | 64 |
| 2 |
|
FC Hennef 05 | 25 | 18 | 4 | 3 | 63:17 | 46 | 58 |
| 3 |
|
SV Bergisch Gladbach 09 | 25 | 16 | 7 | 2 | 60:18 | 42 | 55 |
| 4 |
|
SpVg Frechen 20 | 25 | 15 | 4 | 6 | 57:30 | 27 | 49 |
| 5 |
|
Borussia Freialdenhoven | 25 | 13 | 3 | 9 | 44:36 | 8 | 42 |
| 6 |
|
FC Pesch 1956 | 25 | 10 | 8 | 7 | 53:38 | 15 | 38 |
| 7 |
|
Siegburger SV 04 | 25 | 10 | 8 | 7 | 43:34 | 9 | 38 |
| 8 |
|
Viktoria Arnoldsweiler | 25 | 12 | 2 | 11 | 44:39 | 5 | 38 |
| 9 |
|
BC Viktoria Glesch-Paffendorf | 25 | 10 | 5 | 10 | 38:34 | 4 | 35 |
| 10 |
|
Blau-Weiß Friesdorf | 25 | 9 | 7 | 9 | 39:41 | -2 | 34 |
| 11 |
|
VfL Alfter | 25 | 10 | 4 | 11 | 40:44 | -4 | 34 |
| 12 |
|
FC Hürth | 25 | 10 | 4 | 11 | 35:47 | -12 | 34 |
| 13 |
|
VfL 08 Vichttal | 25 | 9 | 5 | 11 | 45:49 | -4 | 32 |
| 14 |
|
Fortuna Köln II | 25 | 6 | 6 | 13 | 33:47 | -14 | 24 |
| 15 |
|
SV 1914 Eilendorf | 25 | 5 | 4 | 16 | 24:50 | -26 | 19 |
| 16 |
|
SV Breinig | 25 | 5 | 2 | 18 | 32:72 | -40 | 17 |
| 17 |
|
SV Deutz 05 | 25 | 4 | 3 | 18 | 25:60 | -35 | 15 |
| 18 |
|
Spvg Wesseling-Urfeld | 25 | 3 | 0 | 22 | 21:94 | -73 | 9 |
| Playoffs | |
| Abstieg |
