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| 23.09.2021 | 15:00 | Arsenal de Sarandí II | - | Lanús II | 0:0 (0:0) | |
| 15:00 | Independiente II | - | Godoy Cruz II | 0:0 (0:0) | ||
| 24.09.2021 | 15:00 | Aldosivi II | - | Gimnasia de La Plata II | 3:0 (1:0) | |
| 15:00 | Banfield II | - | Atlético Tucumán II | 1:0 (1:0) | ||
| 15:00 | San Lorenzo II | - | Defensa y Justicia II | 0:2 (0:2) | ||
| 15:00 | Sarmiento de Junín II | - | Vélez Sarsfield II | 0:4 (0:2) | ||
| 15:00 | Central Córdoba SdE II | - | River Plate II | 1:2 (1:0) | ||
| 15:00 | Estudiantes II | - | Platense II | 1:1 (1:0) | ||
| 15:00 | Newell's Old Boys II | - | Huracán II | 2:0 (1:0) | ||
| 15:00 | Talleres de Córdoba II | - | Rosario Central II | 3:1 (2:1) | ||
| 15:00 | Unión de Santa Fe II | - | Patronato de Paraná II | 1:1 (1:1) | ||
| 19:00 | Boca Juniors II | - | Colón de Santa Fe II | 3:1 (2:1) | ||
| 27.09.2021 | 15:00 | Argentinos Juniors II | - | Racing Club II | 2:1 (1:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Estudiantes II | 13 | 8 | 5 | 0 | 28:15 | 13 | 29 |
| 2 |
|
Boca Juniors II | 13 | 7 | 3 | 3 | 29:14 | 15 | 24 |
| 3 |
|
River Plate II | 13 | 8 | 0 | 5 | 21:12 | 9 | 24 |
| 4 |
|
Banfield II | 13 | 7 | 3 | 3 | 20:16 | 4 | 24 |
| 5 |
|
Lanús II | 13 | 7 | 2 | 4 | 18:8 | 10 | 23 |
| 6 |
|
Argentinos Juniors II | 13 | 7 | 2 | 4 | 18:15 | 3 | 23 |
| 7 |
|
Colón de Santa Fe II | 13 | 6 | 4 | 3 | 12:9 | 3 | 22 |
| 8 |
|
Rosario Central II | 13 | 6 | 3 | 4 | 28:19 | 9 | 21 |
| 9 |
|
Vélez Sarsfield II | 13 | 5 | 5 | 3 | 19:17 | 2 | 20 |
| 10 |
|
Gimnasia de La Plata II | 13 | 6 | 2 | 5 | 20:19 | 1 | 20 |
| 11 |
|
Platense II | 13 | 5 | 5 | 3 | 15:14 | 1 | 20 |
| 12 |
|
Talleres de Córdoba II | 13 | 5 | 4 | 4 | 15:15 | 0 | 19 |
| 13 |
|
Sarmiento de Junín II | 13 | 5 | 3 | 5 | 16:19 | -3 | 18 |
| 14 |
|
Defensa y Justicia II | 13 | 5 | 3 | 5 | 14:18 | -4 | 18 |
| 15 |
|
Godoy Cruz II | 13 | 4 | 5 | 4 | 15:16 | -1 | 17 |
| 16 |
|
Newell's Old Boys II | 13 | 4 | 4 | 5 | 17:19 | -2 | 16 |
| 17 |
|
Arsenal de Sarandí II | 13 | 4 | 4 | 5 | 11:14 | -3 | 16 |
| 18 |
|
Atlético Tucumán II | 13 | 3 | 6 | 4 | 14:14 | 0 | 15 |
| 19 |
|
San Lorenzo II | 13 | 3 | 5 | 5 | 14:20 | -6 | 14 |
| 20 |
|
Patronato de Paraná II | 13 | 3 | 4 | 6 | 15:23 | -8 | 13 |
| 21 |
|
Independiente II | 13 | 2 | 6 | 5 | 9:15 | -6 | 12 |
| 22 |
|
Racing Club II | 13 | 2 | 5 | 6 | 12:18 | -6 | 11 |
| 23 |
|
Huracán II | 13 | 3 | 2 | 8 | 11:17 | -6 | 11 |
| 24 |
|
Unión de Santa Fe II | 13 | 2 | 5 | 6 | 11:20 | -9 | 11 |
| 25 |
|
Central Córdoba SdE II | 13 | 3 | 1 | 9 | 11:18 | -7 | 10 |
| 26 |
|
Aldosivi II | 13 | 3 | 1 | 9 | 15:24 | -9 | 10 |
