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| 11.12.2021 | 13:00 | GFK Tikvesh | - | FK Bregalnica Štip | 1:3 (1:0) | |
| 12.12.2021 | 13:00 | Akademija Pandev | - | FK Pelister | 1:0 (0:0) | |
| 13:00 | FK Borec | - | KF Shkupi | 0:3 (0:1) | ||
| 13:00 | FK Rabotnički | - | Makedonija GP | 1:2 (0:1) | ||
| 13:00 | KF Shkëndija 79 | - | FK Skopje | 1:0 (0:0) | ||
| 14.12.2021 | 13:00 | FC Struga | - | FK Renova | 1:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
KF Shkupi | 18 | 13 | 3 | 2 | 43:11 | 32 | 42 |
| 2 |
|
Akademija Pandev | 18 | 10 | 5 | 3 | 28:18 | 10 | 35 |
| 3 |
|
KF Shkëndija 79 | 18 | 9 | 7 | 2 | 28:14 | 14 | 34 |
| 4 |
|
FK Bregalnica Štip | 18 | 8 | 5 | 5 | 27:25 | 2 | 29 |
| 5 |
|
FK Renova | 18 | 7 | 6 | 5 | 25:16 | 9 | 27 |
| 6 |
|
Makedonija GP | 18 | 8 | 3 | 7 | 27:31 | -4 | 27 |
| 7 |
|
FC Struga | 18 | 6 | 8 | 4 | 14:14 | 0 | 26 |
| 8 |
|
FK Rabotnički | 18 | 6 | 4 | 8 | 13:19 | -6 | 22 |
| 9 |
|
FK Skopje | 18 | 5 | 5 | 8 | 13:22 | -9 | 20 |
| 10 |
|
GFK Tikvesh | 18 | 3 | 6 | 9 | 16:23 | -7 | 15 |
| 11 |
|
FK Borec | 18 | 3 | 3 | 12 | 16:34 | -18 | 12 |
| 12 |
|
FK Pelister | 18 | 0 | 5 | 13 | 6:29 | -23 | 5 |
| Champions League Quali. | |
| Europa Conference League Quali. | |
| Relegation | |
| Abstieg |
