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| 03.11.2020 | 19:30 | Borussia Dortmund II | - | Preußen Münster | 2:0 (2:0) | |
| 04.11.2020 | 18:00 | SV Lippstadt 08 | - | Fortuna Düsseldorf II | 1:3 (1:1) | |
| 19:30 | 1. FC Köln II | - | SV 19 Straelen | 2:0 (1:0) | ||
| 19:30 | Alemannia Aachen | - | VfB Homberg | 2:0 (1:0) | ||
| 19:30 | Bonner SC | - | Rot-Weiß Oberhausen | 1:6 (0:2) | ||
| 19:30 | FC Wegberg-Beeck | - | Wuppertaler SV | 2:1 (2:0) | ||
| 19:30 | Rot-Weiss Essen | - | SV Rödinghausen | 2:0 (0:0) | ||
| 19:30 | SC Wiedenbrück | - | FC Schalke 04 II | 2:2 (0:1) | ||
| 19:30 | Sportfreunde Lotte | - | SV Bergisch Gladbach 09 | 2:2 (1:0) | ||
| 16.12.2020 | 19:00 | Rot Weiss Ahlen | - | Fortuna Köln | 0:3 (0:1) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Borussia Dortmund II | 12 | 9 | 3 | 0 | 29:8 | 21 | 30 |
| 2 |
|
Rot-Weiss Essen | 12 | 8 | 4 | 0 | 21:6 | 15 | 28 |
| 3 |
|
Fortuna Düsseldorf II | 12 | 7 | 4 | 1 | 27:7 | 20 | 25 |
| 4 |
|
Fortuna Köln | 12 | 7 | 3 | 2 | 26:13 | 13 | 24 |
| 5 |
|
Preußen Münster | 12 | 7 | 2 | 3 | 19:11 | 8 | 23 |
| 6 |
|
Bor. Mönchengladbach II | 12 | 6 | 2 | 4 | 23:14 | 9 | 20 |
| 7 |
|
1. FC Köln II | 12 | 5 | 5 | 2 | 18:12 | 6 | 20 |
| 8 |
|
Alemannia Aachen | 13 | 5 | 4 | 4 | 10:9 | 1 | 19 |
| 9 |
|
FC Schalke 04 II | 13 | 4 | 6 | 3 | 14:10 | 4 | 18 |
| 10 |
|
SV Rödinghausen | 13 | 4 | 5 | 4 | 15:14 | 1 | 17 |
| 11 |
|
SV 19 Straelen | 13 | 4 | 5 | 4 | 16:16 | 0 | 17 |
| 12 |
|
FC Wegberg-Beeck | 12 | 4 | 3 | 5 | 14:16 | -2 | 15 |
| 13 |
|
Rot-Weiß Oberhausen | 13 | 3 | 5 | 5 | 18:22 | -4 | 14 |
| 14 |
|
SV Bergisch Gladbach 09 | 13 | 3 | 5 | 5 | 13:18 | -5 | 14 |
| 15 |
|
SC Wiedenbrück | 12 | 2 | 7 | 3 | 19:24 | -5 | 13 |
| 16 |
|
Wuppertaler SV | 13 | 3 | 3 | 7 | 14:23 | -9 | 12 |
| 17 |
|
Sportfreunde Lotte | 12 | 2 | 4 | 6 | 15:29 | -14 | 10 |
| 18 |
|
SV Lippstadt 08 | 12 | 1 | 6 | 5 | 10:19 | -9 | 9 |
| 19 |
|
Bonner SC | 12 | 2 | 2 | 8 | 11:26 | -15 | 8 |
| 20 |
|
VfB Homberg | 13 | 2 | 1 | 10 | 9:27 | -18 | 7 |
| 21 |
|
Rot Weiss Ahlen | 12 | 1 | 3 | 8 | 13:30 | -17 | 6 |
| Aufstieg | |
| Abstieg |
