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| 23.01.2021 | 14:00 | 1. FC Köln II | - | Borussia Dortmund II | 0:3 (0:1) | |
| 14:00 | Alemannia Aachen | - | Rot Weiss Ahlen | 0:0 (0:0) | ||
| 14:00 | FC Schalke 04 II | - | Rot-Weiß Oberhausen | 0:1 (0:0) | ||
| 14:00 | FC Wegberg-Beeck | - | SC Wiedenbrück | 2:0 (0:0) | ||
| 14:00 | Rot-Weiss Essen | - | Bonner SC | 2:0 (1:0) | ||
| 14:00 | SV Bergisch Gladbach 09 | - | Preußen Münster | 0:1 (0:0) | ||
| 14:00 | SV Rödinghausen | - | Bor. Mönchengladbach II | 2:0 (2:0) | ||
| 14:00 | SV 19 Straelen | - | Fortuna Köln | 0:2 (0:1) | ||
| 14:00 | VfB Homberg | - | Fortuna Düsseldorf II | 3:1 (1:1) | ||
| 14:00 | Wuppertaler SV | - | SV Lippstadt 08 | 3:1 (1:0) |
| » Tabelle | Heim | Auswärts | Hinrunde | Rückrunde | 1. Halbzeit | 2. Halbzeit |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Rot-Weiss Essen | 22 | 16 | 6 | 0 | 48:12 | 36 | 54 |
| 2 |
|
Borussia Dortmund II | 22 | 16 | 5 | 1 | 58:16 | 42 | 53 |
| 3 |
|
Fortuna Köln | 22 | 12 | 7 | 3 | 44:23 | 21 | 43 |
| 4 |
|
Preußen Münster | 22 | 12 | 4 | 6 | 31:19 | 12 | 40 |
| 5 |
|
Fortuna Düsseldorf II | 22 | 10 | 5 | 7 | 41:24 | 17 | 35 |
| 6 |
|
FC Schalke 04 II | 22 | 8 | 9 | 5 | 28:22 | 6 | 33 |
| 7 |
|
1. FC Köln II | 21 | 8 | 8 | 5 | 29:23 | 6 | 32 |
| 8 |
|
Bor. Mönchengladbach II | 22 | 9 | 5 | 8 | 31:27 | 4 | 32 |
| 9 |
|
SV Rödinghausen | 22 | 9 | 5 | 8 | 28:24 | 4 | 32 |
| 10 |
|
Alemannia Aachen | 22 | 8 | 7 | 7 | 19:17 | 2 | 31 |
| 11 |
|
Rot-Weiß Oberhausen | 22 | 7 | 9 | 6 | 32:28 | 4 | 30 |
| 12 |
|
SV 19 Straelen | 22 | 7 | 7 | 8 | 25:34 | -9 | 28 |
| 13 |
|
SC Wiedenbrück | 22 | 5 | 11 | 6 | 29:31 | -2 | 26 |
| 14 |
|
Wuppertaler SV | 22 | 7 | 4 | 11 | 25:38 | -13 | 25 |
| 15 |
|
FC Wegberg-Beeck | 22 | 6 | 6 | 10 | 24:34 | -10 | 24 |
| 16 |
|
SV Lippstadt 08 | 22 | 4 | 10 | 8 | 24:37 | -13 | 22 |
| 17 |
|
VfB Homberg | 22 | 6 | 3 | 13 | 22:42 | -20 | 21 |
| 18 |
|
SV Bergisch Gladbach 09 | 22 | 4 | 6 | 12 | 19:40 | -21 | 18 |
| 19 |
|
Sportfreunde Lotte | 21 | 4 | 5 | 12 | 18:41 | -23 | 17 |
| 20 |
|
Rot Weiss Ahlen | 22 | 2 | 8 | 12 | 23:41 | -18 | 14 |
| 21 |
|
Bonner SC | 22 | 3 | 4 | 15 | 19:44 | -25 | 13 |
| Aufstieg | |
| Abstieg |
