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| 31.07.2022 | 18:40 | Brown de Adrogué | - | Atlanta | 1:2 (1:1) | |
| 20:00 | Sacachispas | - | Güemes de SdE | 0:2 (0:1) | ||
| 20:30 | Deportivo Maipú | - | Gimnasia de Jujuy | 3:0 (2:0) | ||
| 20:40 | Chacarita Juniors | - | Estudiantes de Caseros | 0:1 (0:0) | ||
| 20:40 | Quilmes | - | Almirante Brown | 2:0 (1:0) | ||
| 21:00 | Agropecuario Argentino | - | Gimnasia de Mendoza | 0:1 (0:0) | ||
| 21:00 | Independiente Rivadavia | - | Villa Dálmine | 0:0 (0:0) | ||
| 01.08.2022 | 20:00 | Almagro | - | Temperley | 1:1 (0:0) | |
| 20:00 | Tristan Suárez | - | San Telmo | 0:2 (0:1) | ||
| 20:00 | Guillermo Brown | - | Ramón Santamarina | 1:0 (0:0) | ||
| 20:00 | Nueva Chicago | - | Flandria | 0:1 (0:0) | ||
| 21:00 | Mitre de SdE | - | Deportivo Riestra | 1:1 (1:0) | ||
| 02.08.2022 | 00:00 | Alvarado | - | Deportivo Morón | 0:1 (0:0) | |
| 00:35 | Ferro Carril Oeste | - | Belgrano de Córdoba | 2:0 (1:0) | ||
| 02:00 | San Martín de Tucumán | - | Chaco For Ever | 0:0 (0:0) | ||
| 02:40 | Instituto de Córdoba | - | All Boys | 2:0 (2:0) | ||
| 20:35 | Estudiantes de Río Cuarto | - | Deportivo Madryn | 1:1 (1:0) | ||
| 03.08.2022 | 02:10 | Defensores de Belgrano | - | San Martín de San Juan | 2:0 (1:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 26 | 17 | 6 | 3 | 30:15 | 15 | 57 |
| 2 |
|
San Martín de Tucumán | 26 | 13 | 11 | 2 | 32:15 | 17 | 50 |
| 3 |
|
Instituto de Córdoba | 26 | 14 | 8 | 4 | 33:18 | 15 | 50 |
| 4 |
|
Gimnasia de Mendoza | 26 | 12 | 10 | 4 | 31:12 | 19 | 46 |
| 5 |
|
All Boys | 26 | 11 | 12 | 3 | 37:22 | 15 | 45 |
| 6 |
|
Almagro | 27 | 12 | 7 | 8 | 27:23 | 4 | 43 |
| 7 |
|
Estudiantes de Río Cuarto | 27 | 10 | 12 | 5 | 31:26 | 5 | 42 |
| 8 |
|
Defensores de Belgrano | 26 | 10 | 11 | 5 | 30:21 | 9 | 41 |
| 9 |
|
Independiente Rivadavia | 26 | 10 | 9 | 7 | 33:24 | 9 | 39 |
| 10 |
|
Chaco For Ever | 27 | 8 | 14 | 5 | 27:20 | 7 | 38 |
| 11 |
|
San Martín de San Juan | 27 | 11 | 5 | 11 | 35:30 | 5 | 38 |
| 12 |
|
Brown de Adrogué | 26 | 10 | 8 | 8 | 30:25 | 5 | 38 |
| 13 |
|
Estudiantes de Caseros | 27 | 10 | 8 | 9 | 22:22 | 0 | 38 |
| 14 |
|
Deportivo Maipú | 27 | 8 | 13 | 6 | 32:24 | 8 | 37 |
| 15 |
|
Deportivo Riestra | 26 | 8 | 13 | 5 | 24:21 | 3 | 37 |
| 16 |
|
Deportivo Madryn | 26 | 8 | 12 | 6 | 34:27 | 7 | 36 |
| 17 |
|
Chacarita Juniors | 26 | 9 | 8 | 9 | 37:33 | 4 | 35 |
| 18 |
|
Guillermo Brown | 26 | 10 | 5 | 11 | 22:27 | -5 | 35 |
| 19 |
|
Güemes de SdE | 26 | 8 | 9 | 9 | 22:20 | 2 | 33 |
| 20 |
|
Ferro Carril Oeste | 26 | 8 | 9 | 9 | 22:26 | -4 | 33 |
| 21 |
|
Deportivo Morón | 26 | 6 | 14 | 6 | 18:16 | 2 | 32 |
| 22 |
|
Gimnasia de Jujuy | 26 | 8 | 8 | 10 | 27:34 | -7 | 32 |
| 23 |
|
Agropecuario Argentino | 26 | 6 | 13 | 7 | 22:23 | -1 | 31 |
| 24 |
|
Quilmes | 26 | 7 | 10 | 9 | 30:32 | -2 | 31 |
| 25 |
|
Mitre de SdE | 26 | 7 | 9 | 10 | 26:29 | -3 | 30 |
| 26 |
|
Almirante Brown | 26 | 6 | 12 | 8 | 28:33 | -5 | 30 |
| 27 |
|
Atlanta | 27 | 6 | 11 | 10 | 21:26 | -5 | 29 |
| 28 |
|
Temperley | 26 | 5 | 12 | 9 | 21:29 | -8 | 27 |
| 29 |
|
San Telmo | 26 | 6 | 9 | 11 | 25:39 | -14 | 27 |
| 30 |
|
Alvarado | 27 | 6 | 9 | 12 | 25:41 | -16 | 27 |
| 31 |
|
Atlético Rafaela | 26 | 5 | 11 | 10 | 27:31 | -4 | 26 |
| 32 |
|
Nueva Chicago | 27 | 5 | 10 | 12 | 26:38 | -12 | 25 |
| 33 |
|
Flandria | 26 | 5 | 9 | 12 | 26:36 | -10 | 24 |
| 34 |
|
Villa Dálmine | 26 | 4 | 12 | 10 | 29:43 | -14 | 24 |
| 35 |
|
Tristan Suárez | 26 | 5 | 8 | 13 | 27:33 | -6 | 23 |
| 36 |
|
Sacachispas | 26 | 3 | 14 | 9 | 18:29 | -11 | 23 |
| 37 |
|
Ramón Santamarina | 27 | 4 | 9 | 14 | 18:42 | -24 | 21 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
