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| 02.04.2022 | 02:00 | Estudiantes de Río Cuarto | - | Atlético Rafaela | 0:0 (0:0) | |
| 02:10 | Belgrano de Córdoba | - | All Boys | 2:1 (0:0) | ||
| 02:30 | Gimnasia de Jujuy | - | Chaco For Ever | 1:1 (0:1) | ||
| 20:30 | Flandria | - | San Martín de San Juan | 4:0 (1:0) | ||
| 20:30 | Villa Dálmine | - | Gimnasia de Mendoza | 1:5 (1:2) | ||
| 22:10 | Almagro | - | Chacarita Juniors | 1:3 (1:3) | ||
| 03.04.2022 | 19:30 | Nueva Chicago | - | Brown de Adrogué | 0:0 (0:0) | |
| 20:30 | Alvarado | - | Guillermo Brown | 1:0 (0:0) | ||
| 20:30 | Deportivo Morón | - | Estudiantes de Caseros | 0:1 (0:0) | ||
| 20:30 | Ferro Carril Oeste | - | Agropecuario Argentino | 2:2 (1:1) | ||
| 21:00 | Deportivo Maipú | - | Defensores de Belgrano | 3:1 (1:1) | ||
| 21:00 | Deportivo Madryn | - | Ramón Santamarina | 1:1 (0:0) | ||
| 22:05 | Almirante Brown | - | San Telmo | 1:1 (1:1) | ||
| 04.04.2022 | 00:10 | Temperley | - | Atlanta | 0:2 (0:2) | |
| 01:30 | Independiente Rivadavia | - | Tristan Suárez | 2:1 (0:1) | ||
| 20:40 | Deportivo Riestra | - | Güemes de SdE | 1:0 (0:0) | ||
| 05.04.2022 | 00:05 | Mitre de SdE | - | Instituto de Córdoba | 1:1 (0:1) | |
| 02:10 | Quilmes | - | San Martín de Tucumán | 2:2 (0:1) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 9 | 7 | 1 | 1 | 14:7 | 7 | 22 |
| 2 |
|
Brown de Adrogué | 9 | 5 | 4 | 0 | 15:6 | 9 | 19 |
| 3 |
|
San Martín de Tucumán | 9 | 5 | 3 | 1 | 12:7 | 5 | 18 |
| 4 |
|
Deportivo Riestra | 9 | 4 | 5 | 0 | 7:2 | 5 | 17 |
| 5 |
|
Instituto de Córdoba | 9 | 4 | 5 | 0 | 11:7 | 4 | 17 |
| 6 |
|
Almirante Brown | 9 | 4 | 4 | 1 | 12:9 | 3 | 16 |
| 7 |
|
Guillermo Brown | 9 | 5 | 1 | 3 | 9:7 | 2 | 16 |
| 8 |
|
Chacarita Juniors | 9 | 4 | 2 | 3 | 15:12 | 3 | 14 |
| 9 |
|
Atlanta | 9 | 3 | 4 | 2 | 11:7 | 4 | 13 |
| 10 |
|
All Boys | 8 | 3 | 4 | 1 | 10:7 | 3 | 13 |
| 11 |
|
Chaco For Ever | 9 | 2 | 7 | 0 | 9:6 | 3 | 13 |
| 12 |
|
Deportivo Madryn | 9 | 3 | 4 | 2 | 10:8 | 2 | 13 |
| 13 |
|
Deportivo Maipú | 9 | 3 | 4 | 2 | 9:8 | 1 | 13 |
| 14 |
|
Estudiantes de Caseros | 9 | 3 | 4 | 2 | 8:7 | 1 | 13 |
| 15 |
|
Estudiantes de Río Cuarto | 9 | 3 | 4 | 2 | 7:7 | 0 | 13 |
| 16 |
|
Defensores de Belgrano | 9 | 3 | 3 | 3 | 10:11 | -1 | 12 |
| 17 |
|
Quilmes | 8 | 2 | 5 | 1 | 11:9 | 2 | 11 |
| 18 |
|
Nueva Chicago | 9 | 2 | 5 | 2 | 8:8 | 0 | 11 |
| 19 |
|
Independiente Rivadavia | 8 | 3 | 2 | 3 | 8:9 | -1 | 11 |
| 20 |
|
Agropecuario Argentino | 9 | 2 | 4 | 3 | 9:9 | 0 | 10 |
| 21 |
|
Deportivo Morón | 9 | 2 | 4 | 3 | 5:5 | 0 | 10 |
| 22 |
|
San Martín de San Juan | 9 | 3 | 1 | 5 | 9:10 | -1 | 10 |
| 23 |
|
Alvarado | 9 | 2 | 4 | 3 | 10:14 | -4 | 10 |
| 24 |
|
Gimnasia de Jujuy | 9 | 2 | 4 | 3 | 9:13 | -4 | 10 |
| 25 |
|
Almagro | 9 | 3 | 1 | 5 | 7:13 | -6 | 10 |
| 26 |
|
Gimnasia de Mendoza | 8 | 2 | 3 | 3 | 10:6 | 4 | 9 |
| 27 |
|
Sacachispas | 8 | 1 | 6 | 1 | 9:8 | 1 | 9 |
| 28 |
|
Atlético Rafaela | 9 | 2 | 3 | 4 | 7:8 | -1 | 9 |
| 29 |
|
Temperley | 9 | 2 | 2 | 5 | 8:10 | -2 | 8 |
| 30 |
|
Flandria | 9 | 2 | 2 | 5 | 11:14 | -3 | 8 |
| 31 |
|
Ferro Carril Oeste | 8 | 1 | 4 | 3 | 8:10 | -2 | 7 |
| 32 |
|
Villa Dálmine | 9 | 1 | 4 | 4 | 9:17 | -8 | 7 |
| 33 |
|
San Telmo | 8 | 1 | 4 | 3 | 5:13 | -8 | 7 |
| 34 |
|
Tristan Suárez | 9 | 0 | 6 | 3 | 12:15 | -3 | 6 |
| 35 |
|
Ramón Santamarina | 9 | 1 | 3 | 5 | 9:13 | -4 | 6 |
| 36 |
|
Mitre de SdE | 8 | 0 | 4 | 4 | 5:10 | -5 | 4 |
| 37 |
|
Güemes de SdE | 8 | 0 | 4 | 4 | 4:10 | -6 | 4 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
