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| 25.06.2022 | 01:00 | Quilmes | - | Gimnasia de Mendoza | 0:0 (0:0) | |
| 02:00 | Instituto de Córdoba | - | Estudiantes de Caseros | 1:0 (0:0) | ||
| 19:10 | Deportivo Morón | - | Gimnasia de Jujuy | 1:1 (1:0) | ||
| 21:10 | Alvarado | - | Belgrano de Córdoba | 0:1 (0:0) | ||
| 23:10 | Temperley | - | Flandria | 2:0 (1:0) | ||
| 26.06.2022 | 20:00 | Almagro | - | Deportivo Riestra | 0:1 (0:1) | |
| 20:00 | Deportivo Madryn | - | Almirante Brown | 2:0 (1:0) | ||
| 20:30 | Deportivo Maipú | - | All Boys | 1:1 (1:0) | ||
| 21:00 | Agropecuario Argentino | - | Ramón Santamarina | 1:2 (0:0) | ||
| 21:00 | Mitre de SdE | - | San Martín de San Juan | 0:1 (0:1) | ||
| 21:00 | Estudiantes de Río Cuarto | - | Villa Dálmine | 4:1 (1:1) | ||
| 21:30 | Independiente Rivadavia | - | San Telmo | 4:0 (2:0) | ||
| 23:00 | Tristan Suárez | - | Atlético Rafaela | 4:0 (2:0) | ||
| 27.06.2022 | 01:30 | San Martín de Tucumán | - | Guillermo Brown | 1:0 (0:0) | |
| 20:30 | Sacachispas | - | Atlanta | 0:0 (0:0) | ||
| 23:00 | Ferro Carril Oeste | - | Chaco For Ever | 0:0 (0:0) | ||
| 28.06.2022 | 00:00 | Nueva Chicago | - | Güemes de SdE | 0:2 (0:0) | |
| 02:15 | Defensores de Belgrano | - | Chacarita Juniors | 2:0 (0:0) |
| # | Mannschaft | Sp. | S. | U. | N. | Tore | Dif. | Pk. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Belgrano de Córdoba | 20 | 14 | 4 | 2 | 25:11 | 14 | 46 |
| 2 |
|
San Martín de Tucumán | 20 | 11 | 7 | 2 | 25:14 | 11 | 40 |
| 3 |
|
Instituto de Córdoba | 20 | 10 | 7 | 3 | 25:14 | 11 | 37 |
| 4 |
|
All Boys | 20 | 8 | 11 | 1 | 28:15 | 13 | 35 |
| 5 |
|
Brown de Adrogué | 20 | 9 | 8 | 3 | 26:18 | 8 | 35 |
| 6 |
|
Gimnasia de Mendoza | 20 | 8 | 8 | 4 | 23:12 | 11 | 32 |
| 7 |
|
Independiente Rivadavia | 20 | 9 | 5 | 6 | 29:20 | 9 | 32 |
| 8 |
|
San Martín de San Juan | 21 | 9 | 5 | 7 | 26:21 | 5 | 32 |
| 9 |
|
Estudiantes de Río Cuarto | 21 | 8 | 8 | 5 | 22:20 | 2 | 32 |
| 10 |
|
Almagro | 21 | 9 | 5 | 7 | 19:20 | -1 | 32 |
| 11 |
|
Guillermo Brown | 21 | 9 | 4 | 8 | 20:18 | 2 | 31 |
| 12 |
|
Deportivo Madryn | 21 | 7 | 9 | 5 | 29:22 | 7 | 30 |
| 13 |
|
Deportivo Maipú | 21 | 6 | 12 | 3 | 21:17 | 4 | 30 |
| 14 |
|
Chacarita Juniors | 21 | 7 | 7 | 7 | 31:28 | 3 | 28 |
| 15 |
|
Deportivo Riestra | 20 | 6 | 10 | 4 | 16:15 | 1 | 28 |
| 16 |
|
Estudiantes de Caseros | 21 | 7 | 7 | 7 | 18:19 | -1 | 28 |
| 17 |
|
Chaco For Ever | 21 | 5 | 12 | 4 | 23:18 | 5 | 27 |
| 18 |
|
Defensores de Belgrano | 20 | 6 | 9 | 5 | 20:19 | 1 | 27 |
| 19 |
|
Agropecuario Argentino | 20 | 5 | 11 | 4 | 21:17 | 4 | 26 |
| 20 |
|
Quilmes | 20 | 6 | 8 | 6 | 26:24 | 2 | 26 |
| 21 |
|
Ferro Carril Oeste | 20 | 6 | 8 | 6 | 18:20 | -2 | 26 |
| 22 |
|
Gimnasia de Jujuy | 20 | 6 | 7 | 7 | 21:24 | -3 | 25 |
| 23 |
|
Nueva Chicago | 21 | 5 | 9 | 7 | 21:25 | -4 | 24 |
| 24 |
|
Alvarado | 21 | 6 | 6 | 9 | 20:32 | -12 | 24 |
| 25 |
|
Deportivo Morón | 21 | 4 | 11 | 6 | 13:13 | 0 | 23 |
| 26 |
|
Mitre de SdE | 20 | 5 | 7 | 8 | 21:22 | -1 | 22 |
| 27 |
|
Güemes de SdE | 20 | 5 | 7 | 8 | 15:17 | -2 | 22 |
| 28 |
|
Temperley | 21 | 5 | 7 | 9 | 18:26 | -8 | 22 |
| 29 |
|
Sacachispas | 20 | 3 | 12 | 5 | 17:19 | -2 | 21 |
| 30 |
|
Atlanta | 21 | 4 | 9 | 8 | 18:22 | -4 | 21 |
| 31 |
|
Almirante Brown | 20 | 4 | 9 | 7 | 20:26 | -6 | 21 |
| 32 |
|
Flandria | 20 | 4 | 7 | 9 | 21:27 | -6 | 19 |
| 33 |
|
San Telmo | 20 | 4 | 7 | 9 | 20:35 | -15 | 19 |
| 34 |
|
Atlético Rafaela | 21 | 3 | 9 | 9 | 19:25 | -6 | 18 |
| 35 |
|
Tristan Suárez | 20 | 3 | 7 | 10 | 22:29 | -7 | 16 |
| 36 |
|
Villa Dálmine | 20 | 2 | 10 | 8 | 22:34 | -12 | 16 |
| 37 |
|
Ramón Santamarina | 21 | 2 | 7 | 12 | 14:35 | -21 | 13 |
| Aufstieg | |
| Playoffs | |
| Playoffs | |
| Abstieg |
