 |
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| 14.09.2020 | 14:00 | FC Utrecht | - | Vitesse | 1:2 (0:0) | |
| 15.09.2020 | 17:00 | Inter | - | FC Lugano | 5:0 (4:0) | |
| 18:00 | Sevilla FC | - | Levante UD | 3:2 (0:2) | ||
| 20:00 | Telstar | - | ODIN '59 | 1:3 (1:3) | ||
| 16.09.2020 | 17:00 | PAS Giannina | - | AE Karaiskakis | 1:0 (1:0) | |
| 18:30 | Gimnàstic de Tarragona | - | Real Zaragoza | 1:0 (1:0) | ||
| 19:00 | FC Barcelona | - | Girona FC | 3:1 (2:0) | ||
| 19:30 | CA Bembibre | - | CD Leonesa | 2:6 (1:1) | ||
| 18.09.2020 | 17:30 | Sevilla FC | - | Athletic Bilbao | 2:1 (1:1) | |
| 19.09.2020 | 15:00 | Montrose FC | - | Dundee FC | 2:2 (1:1) | |
| 15:00 | Udinese Calcio | - | SPAL 2013 Ferrara | 0:1 (0:1) | ||
| 16:30 | Calcio Padova | - | AC Reggiana 1919 | 2:1 (1:1) | ||
| 17:00 | Atlético Madrid | - | UD Almería | 4:1 (1:1) | ||
| 17:00 | Modena FC | - | Venezia FC | 1:6 (0:3) | ||
| 17:30 | CD Numancia | - | CD Logroñés | 0:2 (0:1) | ||
| 17:30 | Empoli FC | - | Vis Pesaro | 2:0 (1:0) | ||
| 18:00 | Inter | - | AC Pisa | 7:0 (6:0) | ||
| 18:00 | Lazio Roma | - | Benevento Calcio | 0:0 (0:0) | ||
| 19:00 | FC Barcelona | - | Elche CF | 1:0 (1:0) | ||
| 19:00 | Real Zaragoza | - | Girona FC | 1:0 (0:0) |
