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| H | Chelsea FC | - | Rubin Kazan | 3:1 (2:1) | ||
| R | Rubin Kazan | - | Chelsea FC | 3:2 (0:1) | ||
| H: 04.04.2013 21:05 | R: 11.04.2013 18:00 | Sieger: Chelsea FC | ||||
| H | Tottenham Hotspur | - | FC Basel | 2:2 (1:2) | ||
| R | FC Basel | - | Tottenham Hotspur | 4:1 (1:1, 2:2, 2:2) i.E. | ||
| H: 04.04.2013 21:05 | R: 11.04.2013 21:05 | Sieger: FC Basel | ||||
| H | Fenerbahçe | - | Lazio Roma | 2:0 (0:0) | ||
| R | Lazio Roma | - | Fenerbahçe | 1:1 (0:0) | ||
| H: 04.04.2013 21:05 | R: 11.04.2013 21:05 | Sieger: Fenerbahçe | ||||
| H | SL Benfica | - | Newcastle United | 3:1 (1:1) | ||
| R | Newcastle United | - | SL Benfica | 1:1 (0:0) | ||
| H: 04.04.2013 21:05 | R: 11.04.2013 21:05 | Sieger: SL Benfica | ||||
