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| H | Linfield FC | - | FC Nantes | 0:1 (0:1) | ||
| R | FC Nantes | - | Linfield FC | 2:0 (0:0) | ||
| H: 16.09.1980 18:00 | R: 01.10.1980 20:30 | Sieger: FC Nantes | ||||
| H | ÍBV Vestmannaeyjar | - | TJ Baník Ostrava OKD | 1:1 (1:1) | ||
| R | TJ Baník Ostrava OKD | - | ÍBV Vestmannaeyjar | 1:0 (1:0) | ||
| H: 17.09.1980 | R: 01.10.1980 | Sieger: TJ Baník Ostrava OKD | ||||
| H | Viking FK | - | Crvena Zvezda | 2:3 (1:0) | ||
| R | Crvena Zvezda | - | Viking FK | 4:1 (3:0) | ||
| H: 17.09.1980 | R: 01.10.1980 | Sieger: Crvena Zvezda | ||||
| H | Trabzonspor | - | Szombierki Bytom | 2:1 (1:0) | ||
| R | Szombierki Bytom | - | Trabzonspor | 3:0 (1:0) | ||
| H: 17.09.1980 16:00 | R: 01.10.1980 14:30 | Sieger: Szombierki Bytom | ||||
| H | Dinamo Tiranë | - | AFC Ajax | 0:2 (0:0) | ||
| R | AFC Ajax | - | Dinamo Tiranë | 1:0 (0:0) | ||
| H: 17.09.1980 16:30 | R: 01.10.1980 20:15 | Sieger: AFC Ajax | ||||
| H | BFC Dynamo | - | APOEL Nikosia | 3:0 (0:0) | ||
| R | APOEL Nikosia | - | BFC Dynamo | 2:1 (1:0) | ||
| H: 17.09.1980 17:00 | R: 01.10.1980 20:00 | Sieger: BFC Dynamo | ||||
| H | Limerick United | - | Real Madrid | 1:2 (0:0) | ||
| R | Real Madrid | - | Limerick United | 5:1 (2:1) | ||
| H: 17.09.1980 17:45 | R: 01.10.1980 21:00 | Sieger: Real Madrid | ||||
| H | CSKA Sofia | - | Nottingham Forest | 1:0 (0:0) | ||
| R | Nottingham Forest | - | CSKA Sofia | 0:1 (0:1) | ||
| H: 17.09.1980 18:30 | R: 01.10.1980 19:30 | Sieger: CSKA Sofia | ||||
| H | Olympiakos Piraeus | - | Bayern München | 2:4 (1:1) | ||
| R | Bayern München | - | Olympiakos Piraeus | 3:0 (2:0) | ||
| H: 17.09.1980 18:30 | R: 01.10.1980 20:00 | Sieger: Bayern München | ||||
| H | Aberdeen FC | - | Austria Wien | 1:0 (1:0) | ||
| R | Austria Wien | - | Aberdeen FC | 0:0 (0:0) | ||
| H: 17.09.1980 18:30 | R: 01.10.1980 19:30 | Sieger: Aberdeen FC | ||||
| H | OPS Oulu | - | Liverpool FC | 1:1 (0:1) | ||
| R | Liverpool FC | - | OPS Oulu | 10:1 (4:0) | ||
| H: 17.09.1980 19:00 | R: 01.10.1980 19:30 | Sieger: Liverpool FC | ||||
| H | Halmstads BK | - | Esbjerg fB | 0:0 (0:0) | ||
| R | Esbjerg fB | - | Halmstads BK | 3:2 (2:1) | ||
| H: 17.09.1980 19:00 | R: 01.10.1980 20:00 | Sieger: Esbjerg fB | ||||
| H | Jeunesse Esch | - | Spartak Moskva | 0:5 (0:3) | ||
| R | Spartak Moskva | - | Jeunesse Esch | 4:0 (3:0) | ||
| H: 17.09.1980 19:30 | R: 01.10.1980 18:00 | Sieger: Spartak Moskva | ||||
| H | Club Brugge KV | - | FC Basel | 0:1 (0:0) | ||
| R | FC Basel | - | Club Brugge KV | 4:1 (1:1) | ||
| H: 17.09.1980 20:00 | R: 01.10.1980 20:00 | Sieger: FC Basel | ||||
| H | Inter | - | FC Universitatea Craiova | 2:0 (1:0) | ||
| R | FC Universitatea Craiova | - | Inter | 1:1 (1:1) | ||
| H: 17.09.1980 20:45 | R: 01.10.1980 14:00 | Sieger: Inter | ||||
| H | Sporting CP | - | Budapest Honved SE | 0:2 (0:0) | ||
| R | Budapest Honved SE | - | Sporting CP | 1:0 (1:0) | ||
| H: 17.09.1980 21:30 | R: 01.10.1980 17:30 | Sieger: Budapest Honved SE | ||||
